Luigi Brignoli attended the courses of ' Accademia Carrara in Bergamo as a student of Tallone and Loverini and, for two years, those of the ' Accademia di Brera in Milan. Participates in numerous exhibitions in the meantime, it is appreciated for his landscapes of Lombard tradition and is highly regarded as a portraitist.
Already in his forties and is attracted to North Africa, in 1922 , is with George Oprandi in Algeria, Biskra, where he painted for several months. Then, in 1923 , moves to Tunisia, to then return home the same year and successfully exposing the Artistic Circle Bergamasco its orientalist painting work done in Africa. How Brignoli Orientalist painter eschews exotic forms of rhetoric, but lives the new environment with careful research of color and landscape. In 1926, with Angiolo Alebardi, exhibited at the Galleria Pesaro in Milan.
In the same year to his mentor Loverini going in the direction of ' Accademia Carrara in Bergamo, a position he will retain until 1945 , when it will be replaced by ropes . May 1934 is the exhibition Tripoli, sponsored by the Art Circle Bergamasco. In 1942 he held an exhibition at the Permanente Milan with Cugusi and Della Foglia .